PRP vs PRF, What’s the Difference?

PRP stands for platelet-rich plasma. It is a product that’s used to promote healing when injected into the treated area.  Plasma, the part of the blood that contains special factors or proteins, helps with blood clotting, but also contains proteins that support cell growth. By injecting PRP into damaged tissue, it stimulates the body to grow health new cells that promote the healing response. The growth factors in the prepared PRP are more concentrated than blood and helps the body’s tissue heal faster.

PRF stands for platelet-rich fibrin.  It is very similar to PRP.  Both platelets and fibrin are involved in your body’s natural healing processes, and both PRP and PRF both contain higher-than-normal numbers of platelets for enhanced healing action. New research has shown that a platelet product that has an even higher concentration of platelets, as well as a concentration of white blood cells and stem cells, is even more effective than traditional platelet-rich plasma. With this new information, PRF, or platelet-rich fibrin was created.

The main difference between PRP and PRF is how they’re processed. Both PRP and PRF is taken from your own blood.  Both are spun in a centrifuge machine at high speeds to allow the heavier components of the blood to separate in the container, with the platelets and plasma on one side and the remainder of the of the blood on the other side. 

Both PRP and PRF are versatile treatments used in many cosmetic and medical practices.  Treatments include:

PRP and PRF Are Spun at Different Speeds

With PRF, the blood is spun at a slower speed so that the layers of the blood do not separate out as distinctly as PRP. With the slower speed, the final product still retains some white blood cells, stem cells, and fibrin.  Fibrin is a tough protein product that is arranged in long fibrous chains, a soluble protein found in blood plasma. It is involved in the clotting of blood and is a rich source of autologous cytokines and growth factors.

PRF Offers More Platelet Count

Because PRP is spun at a higher speed, many of the platelets can be left out of the final product. The number of platelets in PRP is generally 3-5 times higher than regular blood, however, the slower speed spun for PRF allows for more platelets in the final product. PRF products contain approximately 10 times the platelet concentration that is found within the body. Thus, there are more healing factors within PRF than in PRP. Also, the lower spin speed causes less trauma to the individual cells of the blood, allowing more stem cells to remain in the final PRF product.

PRP and PRF Release Times are Different

PRP releases more platelets and growth factors more quickly, while PRF releases platelets and growth factors more slowly after injection.

No Anticoagulant Used for PRF

With PRP, blood that is collected is placed in test tubes that have an anticoagulant called acid citrate dextrose (ACD), which keeps the blood product from clotting too quickly. With PRF, no anticoagulant is used during the processing of the blood. To keep the platelet product as natural as possible, the PRF tubes do not have any anticoagulant within them.  Without any anticoagulant in the test tubes, the natural fibrinogen within the blood is converted to fibrin by thrombin in the early stages of clot formation. This creates a spongy fibrin matrix that activates the platelets and allows for a slow release of growth factors, which starts the tissue healing process.

PRP vs PRF: Conclusion

In conclusion, PRF is more effective than PRP.  PRF gives clients the same benefits as PRP, while also releasing more growth factors overtime which means that it continues working for the client even after the procedure is done.  Platelet-rich fibrin also contains greater concentrations of growth factors, as well as stem cells, while PRP does not have stem cells. This higher concentration of growth factors and stem cells will promote more hair regrowth and better improvement in skin treatments than PRP.  Although there are similarities between PRP and PRF, it is the differences between these two products that makes platelet-rich fibrin stand out as a superior treatment option. 

The PRF treatments provide even longer-lasting results as they continue to release growth factors over time. A series of 3 treatments, 3-6 weeks apart provides the most corrective and rejuvenating results.  Our PRP/PRF clinics offers both treatments for hair regrowth, skin rejuvenation, and sexual function.  Please use the contact us form to book a consultation or treatment at one of our clinic locations.

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